Macquarie College traces its beginnings to July 1901 when the Junior School was opened in Lindsay Street, Hamilton. The College transferred to Kemp Street, Hamilton in 1933 providing primary and secondary schooling through to the Leaving Certificate and subsequently to the Higher School Certificate.

In 1990, the Macquarie College Foundation was established with a view to the relocation and expansion of the College program.

In 1992, an 8 hectare site on Lake Road, Wallsend (near Newcastle) was purchased for the new development. In June 1994, the College program was relocated to the new site providing educational services from the Pre-School years (Ages 3-5) through to the Year 12 Higher School Certificate.

The College was officially opened by His Excellency Peter Sinclair AC, Governor of New South Wales on September 18, 1994. Macquarie College has a unique architecturally designed campus with high-quality and specialist facilities. It provides a learning environment that enables young people to optimise their learning-potential and personal development.